دايسر

Dicer 1, ribonuclease type III
	Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer
البنى المتاحة
	2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ
المحددات
الرمزs	DICER1; DCR1; Dicer; Dicer1e; HERNA; K12H4.8-LIKE; MNG1; RMSE2
المحددات الخارجية	OMIM: 606241 MGI: 2177178 هومولوجين: 13251 GeneCards: DICER1 Gene
EC number	3.1.26.3
طبيعة الجين
الوظيفة الجزيئية	• DNA binding; • double-stranded RNA binding; • helicase activity; • endoribonuclease activity; • ribonuclease III activity; • deoxyribonuclease I activity; • protein binding; • ATP binding; • protein domain specific binding; • siRNA binding; • miRNA binding; • metal ion binding; • pre-miRNA binding;
المكون الخلوي	• nucleus; • cytoplasm; • endoplasmic reticulum-Golgi intermediate compartment; • cytosol; • RISC complex; • axon; • dendrite; • growth cone; • ARC complex; • micro-ribonucleoprotein complex; • RISC-loading complex;
العملية الحيوية	• negative regulation of transcription from RNA polymerase II promoter; • angiogenesis; • apoptotic DNA fragmentation; • post-embryonic development; • zygote asymmetric cell division; • gene expression; • negative regulation of Schwann cell proliferation; • positive regulation of gene expression; • regulation of muscle cell apoptotic process; • positive regulation of Schwann cell differentiation; • myoblast differentiation involved in skeletal muscle regeneration; • stem cell maintenance; • spinal cord motor neuron differentiation; • nerve development; • olfactory bulb interneuron differentiation; • cerebral cortex development; • lung development; • production of siRNA involved in RNA interference; • targeting of mRNA for destruction involved in RNA interference; • pre-miRNA processing; • hair follicle morphogenesis; • positive regulation of myelination; • peripheral nervous system myelin formation; • conversion of ds siRNA to ss siRNA involved in RNA interference; • siRNA loading onto RISC involved in RNA interference; • embryonic hindlimb morphogenesis; • production of miRNAs involved in gene silencing by miRNA; • multicellular organism growth; • miRNA loading onto RISC involved in gene silencing by miRNA; • conversion of ds siRNA to ss siRNA; • regulation of viral genome replication; • regulation of neuron differentiation; • mRNA stabilization; • spleen development; • reproductive structure development; • regulation of oligodendrocyte differentiation; • branching morphogenesis of an epithelial tube; • neuron projection morphogenesis; • cartilage development; • spindle assembly; • defense response to virus; • regulation of cell cycle; • cardiac muscle cell development; • inner ear receptor cell development; • intestinal epithelial cell development; • cardiac neural crest cell development involved in outflow tract morphogenesis; • ganglion development; • regulation of enamel mineralization; • hair follicle cell proliferation; • RNA phosphodiester bond hydrolysis, endonucleolytic; • positive regulation of miRNA metabolic process;
نطاقات الپروتين
الكروموسومات المتناددة Orthologs

عدِّل

دايسر بالإنگليزية: Dicer هوإنزيم يدخل في تشكيل الميكروحمض ريبي نووي لدى حقيقيات النوى العليا، لديه أربع مجالات بروتينية.

النطاقات الوظيفية

جزيء واحد لبروتين دايسر من جياردية معوية

دور في تدخل الرنا

The enzyme dicer trims double stranded RNA, to form small interfering RNA or microRNA. These processed RNAs are incorporated into the RNA-induced silencing complex (RISC), which targets messenger RNA to prevent translation.

ميكرورنا

الرنا المتدخـِل الصغير

Formation of miRNA used in RNA interference

انظر أيضاً

gene expression
RISC
RNA interference
microRNA
Small interfering RNA
Drosha
Ribonuclease III
mRNA

المراجع

^ Hammond SM, Bernstein E, Beach D, Hannon GJ (Mar 2000). "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells". Nature. 404 (6775): 293–6. doi:10.1038/35005107. PMID 10749213.