HERPUD1

HERPUD1
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	1WGD
المعهدات
الأسماء المستعارة	HERPUD1, HERP, Mif1, SUP, homocysteine inducible ER protein with ubiquitin like domain 1
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 608070 MGI: MGI:1927406 HomoloGene: 40973 GeneCards: 9709
فهم الوجود الجيني
الوظيفة الجزيئية	• ion channel binding; • ‏GO:0001948 ربط بروتيني; • وظيفة جزيئة; • protein binding, bridging involved in substrate recognition for ubiquitination;
المكونات الخلوية	• مكون تكاملي للغشاء; • Lewy body core; • calcium channel complex; • endoplasmic reticulum membrane; • غشاء; • شبكة إندوبلازمية;
العمليات الحيوية	• negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • ubiquitin-dependent protein catabolic process; • negative regulation of intrinsic apoptotic signaling pathway; • regulation of protein ubiquitination; • regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • cellular calcium ion homeostasis; • endoplasmic reticulum calcium ion homeostasis; • response to endoplasmic reticulum stress; • PERK-mediated unfolded protein response; • positive regulation of ER-associated ubiquitin-dependent protein catabolic process; • regulation of ER-associated ubiquitin-dependent protein catabolic process; • response to unfolded protein; • retrograde protein transport, ER to cytosol; • positive regulation of protein binding; • endoplasmic reticulum unfolded protein response; • protein ubiquitination;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q15011; A4UAE9
	Q9JJK5
	‏NM_001010990، ‏NM_001272103، ‏NM_014685 NM_001010989، ‏NM_001010990، ‏NM_001272103، ‏NM_014685
	‏NM_001357205 NM_022331، ‏NM_001357205
	‏NP_001259032، ‏NP_055500 NP_001010989، ‏NP_001259032، ‏NP_055500; NP_001259032.1
	‏NP_001344134 NP_071726، ‏NP_001344134
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

HERPUD1‏ (Homocysteine inducible ER protein with ubiquitin like domain 1) هوَ بروتين يُشَفر بواسطة جين HERPUD1 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

↑ "Entrez Gene: HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Kokame K, Agarwala KL, Kato H, Miyata T (Nov 2000). "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress". J Biol Chem. 275 (42): 32846–53. doi:10.1074/jbc.M002063200. PMID 10922362.
^ van Laar T, Schouten T, Hoogervorst E, van Eck M, van der Eb AJ, Terleth C (Apr 2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway". FEBS Lett. 469 (1): 123–31. doi:10.1016/S0014-5793(00)01253-9. PMID 10708769.

قراءة متعمقة

van Laar T, van der Eb AJ, Terleth C (2002). "Mif1: a missing link between the unfolded protein response pathway and ER-associated protein degradation?". Curr. Protein Pept. Sci. 2 (2): 169–90. doi:10.2174/1389203013381189. PMID 12370023.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kokame K, Kato H, Miyata T (2001). "Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response". J. Biol. Chem. 276 (12): 9199–205. doi:10.1074/jbc.M010486200. PMID 11112790.
Sai X, Kawamura Y, Kokame K, et al. (2002). "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein". J. Biol. Chem. 277 (15): 12915–20. doi:10.1074/jbc.M112372200. PMID 11799129.
Chtarbova S, Nimmrich I, Erdmann S, et al. (2002). "Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation". Biochem. J. 367 (Pt 3): 723–8. doi:10.1042/BJ20020699. PMC 1222938. PMID 12153396.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sai X, Kokame K, Shiraishi H, et al. (2003). "The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generation". FEBS Lett. 553 (1–2): 151–6. doi:10.1016/S0014-5793(03)01009-3. PMID 14550564.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Schulze A, Standera S, Buerger E, et al. (2006). "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway". J. Mol. Biol. 354 (5): 1021–7. doi:10.1016/j.jmb.2005.10.020. PMID 16289116.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Liang G, Audas TE, Li Y, et al. (2007). "Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element". Mol. Cell. Biol. 26 (21): 7999–8010. doi:10.1128/MCB.01046-06. PMC 1636730. PMID 16940180.
Lenz B, Bleich S, Beutler S, et al. (2007). "Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites". Exp. Cell Res. 312 (20): 4049–55. doi:10.1016/j.yexcr.2006.09.004. PMID 17020760.