AKAP5

AKAP5
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2H9R, 3LL8
المعهدات
الأسماء المستعارة	AKAP5, AKAP75, AKAP79, H21, A-kinase anchoring protein 5
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 604688 MGI: MGI:2685104 HomoloGene: 15854 GeneCards: 9495
فهم الوجود الجيني
الوظيفة الجزيئية	• protein kinase A binding; • calmodulin binding; • ‏GO:0001948 ربط بروتيني; • protein kinase A regulatory subunit binding; • adenylate cyclase binding; • SH3 domain binding; • protein phosphatase 2B binding; • beta-2 adrenergic receptor binding; • ‏GO:0032947 molecular adaptor activity; • glutamate receptor binding; • GABA receptor binding; • scaffold protein binding;
المكونات الخلوية	• عصارة خلوية; • غشاء; • غشاء خلوي; • cytoplasmic side of plasma membrane; • كثافة بعد المشبكي; • dendrite membrane; • dendritic spine; • membrane raft; • excitatory synapse; • داخل خلوي; • خلية;
العمليات الحيوية	• توجيه البروتين; • توصيل الإشارة; • positive regulation of protein kinase A signaling; • chemical synaptic transmission; • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; • negative regulation of adenylate cyclase activity; • regulation of protein kinase A signaling; • positive regulation of adenylate cyclase activity; • positive regulation of protein localization to plasma membrane;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P24588; Q6PG46
	D3YVF0
	NM_004857
	‏XM_006515842 NM_001101471، ‏XM_006515842
	NP_004848; NP_004848.3
	‏XP_006515905 NP_001094941، ‏XP_006515905
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

AKAP5‏ (A-kinase anchoring protein 5) هوَ بروتين يُشَفر بواسطة جين AKAP5 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J Biol Chem. 267 (19): 13376–82. PMID 1618839.
^ Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79". J Biol Chem. 267 (24): 16816–23. PMID 1512224.

قراءة متعمقة

Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
Hirsch AH, Glantz SB, Li Y, et al. (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta". J. Biol. Chem. 267 (4): 2131–4. PMID 1733921.
Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem. 266 (22): 14188–92. PMID 1860836.
Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108–11. doi:10.1126/science.7528941. PMID 7528941.
Glantz SB, Li Y, Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton". J. Biol. Chem. 268 (17): 12796–804. PMID 8509414.
Faux MC, Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin". J. Biol. Chem. 272 (27): 17038–44. doi:10.1074/jbc.272.27.17038. PMID 9202019.
Kashishian A, Howard M, Loh C, et al. (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
Paolillo M, Feliciello A, Porcellini A, et al. (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells". J. Biol. Chem. 274 (10): 6546–52. doi:10.1074/jbc.274.10.6546. PMID 10037748.
Dodge KL, Carr DW, Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover". Endocrinology. 140 (11): 5165–70. doi:10.1210/en.140.11.5165. PMID 10537145.
Fraser ID, Cong M, Kim J, et al. (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409–12. doi:10.1016/S0960-9822(00)00419-X. PMID 10753752.
Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci. 12 (4): 1155–64. doi:10.1046/j.1460-9568.2000.00002.x. PMID 10762347.
Colledge M, Dean RA, Scott GK, et al. (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron. 27 (1): 107–19. doi:10.1016/S0896-6273(00)00013-1. PMID 10939335.
Indolfi C, Stabile E, Coppola C, et al. (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals". Circ. Res. 88 (3): 319–24. doi:10.1161/01.res.88.3.319. PMID 11179200.
Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1". J. Biol. Chem. 276 (23): 20499–505. doi:10.1074/jbc.M101425200. PMID 11287423.
Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (4): G1051–8. PMID 11557526.