FBXO32

FBXO32
المعهدات
الأسماء المستعارة	FBXO32, Fbx32, MAFbx, F-box protein 32
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 606604 MGI: MGI:1914981 HomoloGene: 12182 GeneCards: 114907
فهم الوجود الجيني
الوظيفة الجزيئية	• ‏GO:0001948 ربط بروتيني; • ubiquitin-protein transferase activity;
المكونات الخلوية	• سيتوبلازم; • Z disc; • بلازم نووي; • عصارة خلوية; • نواة; • SCF ubiquitin ligase complex;
العمليات الحيوية	• response to denervation involved in regulation of muscle adaptation; • cellular response to dexamethasone stimulus; • protein polyubiquitination; • protein ubiquitination; • تعديل ما بعد الترجمة;
	المصادر:Amigo / QuickGO
أورثولوج
	Q969P5
	Q9CPU7
	‏NM_001242463، ‏NM_058229 NM_148177، ‏NM_001242463، ‏NM_058229
	NM_026346
	‏NP_478136، ‏NP_680482 NP_001229392، ‏NP_478136، ‏NP_680482
	NP_080622
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

FBXO32‏ (F-box protein 32) هوَ بروتين يُشَفر بواسطة جين FBXO32 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: FBXO32 F-box protein 32". مؤرشف من الأصل في 05 ديسمبر 2010.
^ Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ (Nov 2001). "Identification of ubiquitin ligases required for skeletal muscle atrophy". Science. 294 (5547): 1704–8. doi:10.1126/science.1065874. PMID 11679633.
^ Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL (Dec 2001). "Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14440–5. doi:10.1073/pnas.251541198. PMC 64700. PMID 11717410.

قراءة متعمقة

Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH (2007). "The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity". J. Clin. Invest. 117 (12): 3940–51. doi:10.1172/JCI32741. PMC 2066198. PMID 17992259.
de Palma L, Marinelli M, Pavan M, Orazi A (2008). "Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophy". Joint Bone Spine. 75 (1): 53–7. doi:10.1016/j.jbspin.2007.04.019. PMID 17977773.
Mascher H, Tannerstedt J, Brink-Elfegoun T, Ekblom B, Gustafsson T, Blomstrand E (2008). "Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 294 (1): E43-51. doi:10.1152/ajpendo.00504.2007. PMID 17971512.
de Boer MD, Selby A, Atherton P, Smith K, Seynnes OR, Maganaris CN, Maffulli N, Movin T, Narici MV, Rennie MJ (2007). "The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse". J. Physiol. 585 (Pt 1): 241–51. doi:10.1113/jphysiol.2007.142828. PMC 2375459. PMID 17901116.
Petersen AM, Magkos F, Atherton P, Selby A, Smith K, Rennie MJ, Pedersen BK, Mittendorfer B (2007). "Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle". Am. J. Physiol. Endocrinol. Metab. 293 (3): E843-8. doi:10.1152/ajpendo.00301.2007. PMID 17609255.
Kostek MC, Chen YW, Cuthbertson DJ, Shi R, Fedele MJ, Esser KA, Rennie MJ (2007). "Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32". Physiol. Genomics. 31 (1): 42–52. doi:10.1152/physiolgenomics.00151.2006. PMID 17519359.
Doucet M, Russell AP, Léger B, Debigaré R, Joanisse DR, Caron MA, LeBlanc P, Maltais F (2007). "Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease". Am. J. Respir. Crit. Care Med. 176 (3): 261–9. doi:10.1164/rccm.200605-704OC. PMID 17478621.
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Léger B, Vergani L, Sorarù G, Hespel P, Derave W, Gobelet C, D'Ascenzio C, Angelini C, Russell AP (2006). "Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1". FASEB J. 20 (3): 583–5. doi:10.1096/fj.05-5249fje. PMID 16507768.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.