FLT4

FLT4
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	4BSJ, 4BSK
المعهدات
الأسماء المستعارة	FLT4, 1, LMPH1A, PCL, VEGFR3, FLT-4, VEGFR-3, fms related tyrosine kinase 4, LMPHM1, fms related receptor tyrosine kinase 4, CHTD7
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 136352 MGI: MGI:95561 HomoloGene: 7321 GeneCards: 2324
فهم الوجود الجيني
الوظيفة الجزيئية	• vascular endothelial growth factor-activated receptor activity; • نشاط انتنطقي; • nucleotide binding; • protein kinase activity; • growth factor binding; • kinase activity; • ‏GO:0001948 ربط بروتيني; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • protein phosphatase binding; • ATP binding; • VEGF-C-activated receptor activity; • protein homodimerization activity; • receptor tyrosine kinase; • transmembrane signaling receptor activity; • vascular endothelial growth factor binding;
المكونات الخلوية	• سيتوبلازم; • مكون تكاملي للغشاء; • غشاء; • receptor complex; • غشاء خلوي; • integral component of plasma membrane; • منطقة خارج الخلية; • نواة; • بلازم نووي;
العمليات الحيوية	• regulation of blood vessel remodeling; • positive regulation of protein phosphorylation; • positive regulation of endothelial cell proliferation; • blood vessel morphogenesis; • lymphangiogenesis; • فسفرة; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of protein kinase C signaling; • negative regulation of apoptotic process; • sprouting angiogenesis; • positive regulation of JNK cascade; • lymph vessel development; • positive regulation of endothelial cell migration; • protein phosphorylation; • vascular endothelial growth factor receptor signaling pathway; • vasculature development; • توليد الأوعية; • ضبط زيادي للتكاثر الخلوي; • positive regulation of ERK1 and ERK2 cascade; • autophosphorylation; • positive regulation of vascular endothelial growth factor production; • peptidyl-tyrosine phosphorylation; • cellular response to vascular endothelial growth factor stimulus; • positive regulation of MAPK cascade; • lung alveolus development; • respiratory system process; • respiratory gaseous exchange; • vascular endothelial growth factor signaling pathway; • negative regulation of signal transduction; • تمايز خلوي; • positive regulation of phosphatidylinositol 3-kinase signaling;
	المصادر:Amigo / QuickGO
أورثولوج
	P35916
	P35917
	‏NM_182925، ‏XM_011534478، ‏XM_011534484، ‏XM_017009263، ‏XM_017009264، ‏XM_017009265، ‏XM_017009266، ‏XM_017009267، ‏XM_017009268، ‏XR_001742050، ‏NM_001354989 NM_002020، ‏NM_182925، ‏XM_011534478، ‏XM_011534484، ‏XM_017009263، ‏XM_017009264، ‏XM_017009265، ‏XM_017009266، ‏XM_017009267، ‏XM_017009268، ‏XR_001742050، ‏NM_001354989
	NM_008029
	‏NP_891555، ‏XP_011532780، ‏XP_011532786، ‏XP_016864752، ‏XP_016864753، ‏XP_016864754، ‏XP_016864755، ‏XP_016864756، ‏XP_016864757، ‏NP_001341918 NP_002011، ‏NP_891555، ‏XP_011532780، ‏XP_011532786، ‏XP_016864752، ‏XP_016864753، ‏XP_016864754، ‏XP_016864755، ‏XP_016864756، ‏XP_016864757، ‏NP_001341918
	NP_032055
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

FLT4‏ (Fms related tyrosine kinase 4) هوَ بروتين يُشَفر بواسطة جين FLT4 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene". Genomics. 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394.
↑ "Entrez Gene: FLT4 fms-related tyrosine kinase 4". مؤرشف من الأصل فيستة مارس 2010.

قراءة متعمقة

Petrova TV, Makinen T, Alitalo K (November 1999). "Signaling via vascular endothelial growth factor receptors". Experimental Cell Research. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, McMahon J, Wasmuth J, Huebner K, Alitalo K (February 1992). "FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter". Cancer Research. 52 (3): 746–8. PMID 1310071.
Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene". Genomics. 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394.
Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K (October 1992). "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines". Cancer Research. 52 (20): 5738–43. PMID 1327515.
Fournier E, Dubreuil P, Birnbaum D, Borg JP (September 1995). "Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor". Oncogene. 11 (5): 921–31. PMID 7675451.
Pajusola K, Aprelikova O, Armstrong E, Morris S, Alitalo K (November 1993). "Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts". Oncogene. 8 (11): 2931–7. PMID 7692369.
Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K (December 1994). "Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors". Oncogene. 9 (12): 3545–55. PMID 7970715.
Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D (May 1993). "The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor". Oncogene. 8 (5): 1233–40. PMID 8386825.
Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP (May 1996). "Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase". The Journal of Biological Chemistry. 271 (22): 12956–63. doi:10.1074/jbc.271.22.12956. PMID 8662748.
Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI (March 1996). "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4". Proceedings of the National Academy of Sciences of the United States of America. 93 (5): 1988–92. doi:10.1073/pnas.93.5.1988. PMC 39896. PMID 8700872.
Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V, Alitalo K (December 1996). "VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development". Development. 122 (12): 3829–37. PMID 9012504.
Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA (January 1998). "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor ثلاثة (Flt4)". Proceedings of the National Academy of Sciences of the United States of America. 95 (2): 548–53. doi:10.1073/pnas.95.2.548. PMC 18457. PMID 9435229.
Ferrell RE, Levinson KL, Esman JH, Kimak MA, Lawrence EC, Barmada MM, Finegold DN (December 1998). "Hereditary lymphedema: evidence for linkage and genetic heterogeneity". Human Molecular Genetics. 7 (13): 2073–8. doi:10.1093/hmg/7.13.2073. PMID 9817924.
Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP (January 1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor ثلاثة signaling". Oncogene. 18 (2): 507–14. doi:10.1038/sj.onc.1202315. PMID 9927207.
Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN (June 2000). "Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema". Nature Genetics. 25 (2): 153–9. doi:10.1038/75997. PMID 10835628.
Irrthum A, Karkkainen MJ, Devriendt K, Alitalo K, Vikkula M (August 2000). "Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase". American Journal of Human Genetics. 67 (2): 295–301. doi:10.1086/303019. PMC 1287178. PMID 10856194.
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Baldwin ME, Roufail S, Halford MM, Alitalo K, Stacker SA, Achen MG (November 2001). "Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis". The Journal of Biological Chemistry. 276 (47): 44307–14. doi:10.1074/jbc.M106188200. PMID 11574540.
Walter JW, North PE, Waner M, Mizeracki A, Blei F, Walker JW, Reinisch JF, Marchuk DA (March 2002). "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma". Genes, Chromosomes & Cancer. 33 (3): 295–303. doi:10.1002/gcc.10028. PMID 11807987.