RGS14

RGS14
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2JNU, 2OM2, 2XNS, 3ONW, 3QI2
المعهدات
الأسماء المستعارة	RGS14, regulator of G protein signaling 14
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602513 MGI: MGI:1859709 HomoloGene: 4735 GeneCards: 10636
فهم الوجود الجيني
الوظيفة الجزيئية	• GTPase activating protein binding; • GTPase activator activity; • GTPase regulator activity; • microtubule binding; • ‏GO:0001948 ربط بروتيني; • GDP-dissociation inhibitor activity; • G-protein alpha-subunit binding; • receptor signaling complex scaffold activity; • protein kinase binding; • GTPase activity;
المكونات الخلوية	• سيتوبلازم; • PML body; • جسيم مركزي; • postsynaptic membrane; • إسقاط خلية; • spindle pole; • نقاط نووية; • غشاء; • كثافة بعد المشبكي; • غشاء خلوي; • جهاز مغزلي; • dendritic spine; • تشابك عصبي; • microtubule organizing center; • موصل خلوي; • تغصن; • أنيبيب دقيق; • هيكل خلوي; • نواة; • glutamatergic synapse;
العمليات الحيوية	• التفهم البصري; • intracellular signal transduction; • regulation of G-protein coupled receptor protein signaling pathway; • chromosome segregation; • تفهم; • response to oxidative stress; • انقسام خلوي; • positive regulation of neurogenesis; • positive regulation of GTPase activity; • spindle organization; • ذاكرة طويلة الأمد; • negative regulation of MAP kinase activity; • nucleocytoplasmic transport; • zygote asymmetric cell division; • negative regulation of ERK1 and ERK2 cascade; • دورة الخلية; • platelet-derived growth factor receptor signaling pathway; • negative regulation of signal transduction; • regulation of DNA-templated transcription in response to stress; • negative regulation of synaptic plasticity; • توصيل الإشارة; • long-term synaptic potentiation; • mitotic cell cycle; • negative regulation of G-protein coupled receptor protein signaling pathway; • modulation of chemical synaptic transmission; • G-protein coupled receptor signaling pathway; • positive regulation of signal transduction;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ; ; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	O43566
	P97492
	‏XM_024454328، ‏NM_001366617، ‏NM_001366618 NM_006480، ‏XM_024454328، ‏NM_001366617، ‏NM_001366618
	‏NM_001360714 NM_016758، ‏NM_001360714
	‏XP_024310096، ‏NP_001353546، ‏NP_001353547 NP_006471، ‏XP_024310096، ‏NP_001353546، ‏NP_001353547
	‏NP_001347643 NP_058038، ‏NP_001347643
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

RGS14‏ (Regulator of G protein signaling 14) هوَ بروتين يُشَفر بواسطة جين RGS14 في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ "Entrez Gene: RGS14 regulator of G-protein signalling 14". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

Snow BE, Antonio L, Suggs S, et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
Traver S, Bidot C, Spassky N, et al. (2001). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". Biochem. J. 350 (1): 19–29. doi:10.1042/0264-6021:3500019. PMC 1221220. PMID 10926822.
Cho H, Kozasa T, Takekoshi K, et al. (2000). "RGS14, a GTPase-activating protein for Gialpha, attenuates Gialpha- and G13alpha-mediated signaling pathways". Mol. Pharmacol. 58 (3): 569–76. PMID 10953050.
Hollinger S, Taylor JB, Goldman EH, Hepler JR (2001). "RGS14 is a bifunctional regulator of Gi/oalpha activity that exists in multiple populations in brain". Journal of Neurochemistry. 79 (5): 941–49. doi:10.1046/j.1471-4159.2001.00629.x. PMID 11739605.
Kimple RJ, De Vries L, Tronchère H, et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Kimple RJ, Kimple ME, Betts L, et al. (2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature. 416 (6883): 878–81. doi:10.1038/416878a. PMID 11976690.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hollinger S, Ramineni S, Hepler JR (2003). "Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.". Biochemistry. 42 (3): 811–9. doi:10.1021/bi026664y. PMID 12534294.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, et al. (2004). "RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote". Dev. Cell. 7 (5): 763–9. doi:10.1016/j.devcel.2004.10.004. PMID 15525537.
Martin-McCaffrey L, Willard FS, Pajak A, et al. (2006). "RGS14 is a microtubule-associated protein". Cell Cycle. 4 (7): 953–60. doi:10.4161/cc.4.7.1787. PMID 15917656.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Shu FJ, Ramineni S, Amyot W, Hepler JR (2007). "Selective interactions between Gialpha1 and Gialpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization". Cellular Signalling. 19 (1): 941–49. doi:10.1016/j.cellsig.2006.06.002. PMID 16870394.
Shu FJ, Ramineni S, Hepler JR (2009). "RGS14 is multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signaling pathways". Cellular Signalling.: in press.