RPS27A

RPS27A
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معهدات بنك بيانات البروتين
	2KTF, 2L0F, 2L0T, 2XK5, 3AXC, 3NHE, 3NOB, 3PHW, 3TBL, 4UG0, 4V6X, 5AJ0, 4R62, 5FLX, 4UJD, 4KZZ, 4UJC, 3J7P, 4KZY, 4D5L, 3J7R, 4D61, 4KZX, 4UJE, 5A2Q
المعهدات
الأسماء المستعارة	RPS27A, CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, ribosomal protein S27a
معهدات خارجية	الوراثة المندلية البشرية عبر الإنترنت 191343 MGI: MGI:1925544 HomoloGene: 37715 GeneCards: 6233
فهم الوجود الجيني
الوظيفة الجزيئية	• ربط أيون فلزي; • structural constituent of ribosome; • ‏GO:0001948 ربط بروتيني; • RNA binding; • protein tag; • ubiquitin protein ligase binding;
المكونات الخلوية	• سيتوبلازم; • endocytic vesicle membrane; • عصارة خلوية; • غشاء; • نواة; • ريبوسوم; • ميالين; • cytosolic small ribosomal subunit; • نوية; • extracellular exosome; • غشاء خلوي; • بلازم نووي; • small ribosomal subunit; • endosome membrane; • خارج خلوي; • mitochondrial outer membrane; • endoplasmic reticulum quality control compartment; • حويصل; • endoplasmic reticulum membrane; • host cell;
العمليات الحيوية	• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • negative regulation of epidermal growth factor receptor signaling pathway; • interstrand cross-link repair; • nucleotide-excision repair, DNA damage recognition; • positive regulation of canonical Wnt signaling pathway; • tumor necrosis factor-mediated signaling pathway; • regulation of type I interferon production; • TRIF-dependent toll-like receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • endosomal transport; • global genome nucleotide-excision repair; • NIK/NF-kappaB signaling; • G2/M transition of mitotic cell cycle; • stress-activated MAPK cascade; • transforming growth factor beta receptor signaling pathway; • macroautophagy; • negative regulation of canonical Wnt signaling pathway; • DNA damage response, detection of DNA damage; • nucleotide-excision repair, DNA gap filling; • viral transcription; • error-free translesion synthesis; • regulation of tumor necrosis factor-mediated signaling pathway; • stimulatory C-type lectin receptor signaling pathway; • negative regulation of transforming growth factor beta receptor signaling pathway; • SRP-dependent cotranslational protein targeting to membrane; • JNK cascade; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • nucleotide-excision repair, DNA incision; • I-kappaB kinase/NF-kappaB signaling; • مناعة فطرية; • Notch signaling pathway; • regulation of mRNA stability; • protein polyubiquitination; • negative regulation of apoptotic process; • negative regulation of transcription from RNA polymerase II promoter; • virion assembly; • activation of MAPK activity; • positive regulation of NF-kappaB transcription factor activity; • anaphase-promoting complex-dependent catabolic process; • negative regulation of type I interferon production; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • nucleotide-binding oligomerization domain containing signaling pathway; • عملية التمثيل الغذائي للبروتين الخلوي; • intracellular transport of virus; • دورة حياة الفيروس; • MyD88-dependent toll-like receptor signaling pathway; • error-prone translesion synthesis; • MAPK cascade; • fibroblast growth factor receptor signaling pathway; • ion transmembrane transport; • glycogen biosynthetic process; • positive regulation of apoptotic process; • translational initiation; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • translesion synthesis; • transcription-coupled nucleotide-excision repair; • T cell receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • regulation of signal transduction by p53 class mediator; • positive regulation of epidermal growth factor receptor signaling pathway; • Wnt signaling pathway; • nucleotide-excision repair, DNA duplex unwinding; • nucleotide-excision repair, DNA incision, 5'-to lesion; • اصطناع حيوي للبروتين; • rRNA processing; • ERBB2 signaling pathway; • Wnt signaling pathway, planar cell polarity pathway; • nucleotide-excision repair, preincision complex assembly; • proteasome-mediated ubiquitin-dependent protein catabolic process; • طي البروتين; • negative regulation of G2/M transition of mitotic cell cycle; • protein ubiquitination; • protein deubiquitination; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • entry of bacterium into host cell; • نقل عبر الغشاء; • regulation of necroptotic process; • membrane organization; • endoplasmic reticulum mannose trimming; • cellular iron ion homeostasis; • regulation of hematopoietic stem cell differentiation; • protein targeting to peroxisome; • cytokine-mediated signaling pathway; • modification-dependent protein catabolic process; • interleukin-1-mediated signaling pathway;
	المصادر:Amigo / QuickGO
أورثولوج
	P62979
	P62983
	‏NM_001135592، ‏NM_001177413 NM_002954، ‏NM_001135592، ‏NM_001177413
	‏NM_024277 NM_001033865، ‏NM_024277
	‏NP_001170884، ‏NP_002945 NP_001129064، ‏NP_001170884، ‏NP_002945
	‏NP_077239 NP_001029037، ‏NP_077239
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

RPS27A‏ (Ribosomal protein S27a) هوَ بروتين يُشَفر بواسطة جين RPS27A في الإنسان.

الوظيفة

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

الأهمية السريرية

هذا القسم فارغ أوغير مكتمل، ساهم بتحريره.

المراجع

^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ "Entrez Gene: RPS27A ribosomal protein S27a". مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Adams SM, Sharp MG, Walker RA, et al. (1992). "Differential expression of translation-associated genes in benign and malignant human breast tumours". Br. J. Cancer. 65 (1): 65–71. doi:10.1038/bjc.1992.12. PMC 1977345. PMID 1370760.
Pancré V, Pierce RJ, Fournier F, et al. (1991). "Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL)". Eur. J. Immunol. 21 (11): 2735–41. doi:10.1002/eji.1830211113. PMID 1657614.
Kanayama H, Tanaka K, Aki M, et al. (1992). "Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells". Cancer Res. 51 (24): 6677–85. PMID 1660345.
Monia BP, Ecker DJ, Jonnalagadda S, et al. (1989). "Gene synthesis, expression, and processing of human ubiquitin carboxyl extension proteins". J. Biol. Chem. 264 (7): 4093–103. PMID 2537304.
Redman KL, Rechsteiner M (1989). "Identification of the long ubiquitin extension as ribosomal protein S27a". Nature. 338 (6214): 438–40. doi:10.1038/338438a0. PMID 2538756.
Lund PK, Moats-Staats BM, Simmons JG, et al. (1985). "Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor". J. Biol. Chem. 260 (12): 7609–13. PMID 2581967.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kirschner LS, Stratakis CA (2000). "Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes". Biochem. Biophys. Res. Commun. 270 (3): 1106–10. doi:10.1006/bbrc.2000.2568. PMID 10772958.
Petersen BO, Wagener C, Marinoni F, et al. (2000). "Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1". Genes Dev. 14 (18): 2330–43. doi:10.1101/gad.832500. PMC 316932. PMID 10995389.
Bolton D, Evans PA, Stott K, Broadhurst RW (2002). "Structure and properties of a dimeric N-terminal fragment of human ubiquitin". J. Mol. Biol. 314 (4): 773–87. doi:10.1006/jmbi.2001.5181. PMID 11733996.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cohen BD, Bariteau JT, Magenis LM, Dias JA (2003). "Regulation of follitropin receptor cell surface residency by the ubiquitin-proteasome pathway". Endocrinology. 144 (10): 4393–402. doi:10.1210/en.2002-0063. PMID 12960054.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.